In India, Hindus call a three-pronged spear a trishul. The prongs symbolize nature, in its creative, preservative, and destructive states. Cancer research aims are akin to those natural states. Rapid cellular division is the creative state, for which chemotherapy and radiation, (or most recently synchronous chemoradiation), are used to kill the rapidly dividing cells. Angiogenesis meets a preservative requirement, bringing blood flow to tumors. Metastasis is a resulting destructive oncogenic state. Oncologist clinicians require an evolving therapy plan – a plan to wield like a specialized weapon to hit moving targets. Many clinical trials are now involving multiple drugs in synchronized or sequenced treatments. They hope to overcome obstacles like drug resistance…to promote synergistic drug actions…all to achieve improved patient … Continue reading →