Tag Archives: oncology

The beginning of a new year is a time for reflection. There have been two news items which have struck me in regard to epigenetics and cancer research, recently. Dr. James Watson, Nobel Prize winner, and co-discoverer of the double helix structure of DNA, has published a controversial, open access paper in the journal Open Biology. Cancer research has not produced cures, but merely temporary life extentions for those facing metastatic cancers. The sequencing of the human genome and identification of individual cancer cell mutation drivers of disease, have not produced cures. Dr. Watson points out that once cancer turns metastatic, resistance to gene-targeted drugs is rampant. In the metastatic process, DNA sequence mutations often don’t change. Rather their expression … Continue reading

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Cancer is a strong focus of epigenetic research. A critical issue in oncology is that average cancer treatment isn’t producing the best outcomes for the majority of people. Drug companies trying to produce effective treatments for the average of the population, struggle with poor results in large scale clinical trials. Patients are clamoring for personalized medicine. To meet this goal, clinicians need cancer biomarkers. Through excellent research efforts, epigenomics is adding a richer temporal dimension into our view of oncogenesis. Epigenetic regulation mechanisms act as a group of musicians playing from the composition of the genetic code. They play as a large orchestra of integrated gene networks, keeping cells on a differentiated path. Researchers have identified three main sections in … Continue reading

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