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Author  |
Padeganeh, A.; De Rop, V.; Maddox, P.S. |
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Title |
Nucleosomal composition at the centromere: a numbers game |
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Journal Article |
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Year |
2013 |
Publication |
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology |
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Chromosome Res |
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Abstract |
The Centromere is a unique chromosomal locus where the kinetochore is formed to mediate faithful chromosome partitioning, thus maintaining ploidy during cell division. Centromere identity is inherited via an epigenetic mechanism involving a histone H3 variant, called centromere protein A (CENP-A) which replaces H3 in centromeric chromatin. In spite of extensive efforts in field of centromere biology during the past decade, controversy persists over the structural nature of the CENP-A-containing epigenetic mark, both at nucleosomal and chromatin levels. Here, we review recent findings and hypotheses regarding the structure of CENP-A-containing complexes. |
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Address |
Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, H3T1J4, QC, Canada |
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Language |
English |
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ISSN |
0967-3849 |
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Notes |
PMID:23328870 |
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Call Number |
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37341 |
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