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Author (up) Knower, K.C.; To, S.Q.; Clyne, C.D.
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  Title Intracrine oestrogen production and action in breast cancer: An epigenetic focus Type Journal Article
  Year 2013 Publication The Journal of Steroid Biochemistry and Molecular Biology Abbreviated Journal J Steroid Biochem Mol Biol  
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  Abstract Epigenome changes have been widely demonstrated to contribute to the initiation and progression of a vast array of cancers including breast cancer. The reversible process of many epigenetic modifications is thus an attractive feature for the development of novel therapeutic measures. In oestrogen receptor alpha (hereinafter referred to as ER) positive tumours, endocrine therapies have proven beneficial in patient care, particularly in postmenopausal women where two-thirds of tumours are oestrogen dependent. However, resistance to such therapies is a common feature amongst individuals. In the current review, we discuss the influence that epigenetics has on oestrogen dependent breast cancers, in particular (i) the production of intracrine oestrogen in postmenopausal women (ii) the action of oestrogen on epigenetic processes and (iii) the links between epigenetics and endocrine resistance and the current advancements in epigenetic therapy that target this process.  
  Address Cancer Drug Discovery, Prince Henry's Institute, Clayton, Victoria, Australia. Electronic address: kevin.knower@princehenrys.org  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0960-0760 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23339934 Approved no  
  Call Number @ @ Serial 37355  
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