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Author (up) O'Rourke, C.J.; Knabben, V.; Bolton, E.; Moran, D.; Lynch, T.; Hollywood, D.; Perry, A.S.
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  Title Manipulating the Epigenome for the Treatment of Urological Malignancies Type Journal Article
  Year 2013 Publication Pharmacology & Therapeutics Abbreviated Journal Pharmacol Ther  
  Volume Issue Pages  
  Keywords  
  Abstract Urological malignancies (cancers of the prostate, bladder, kidney and testes) account for 15% of all human cancers and more than 500,000 deaths worldwide each year. This group of malignancies is spread across multiple generations, affecting the young (testicular) through middle and old-age (kidney, prostate and bladder). Like most human cancers, urological cancers are characterized by widespread epigenetic insult, causing changes in DNA hypermethylation and histone modifications leading to silencing of tumor suppressor genes and genomic instability. The inherent stability yet dynamic plasticity of the epigenome lends itself well to therapeutic manipulation. Epigenetic changes are amongst the earliest lesions to occur during carcinogenesis and are essentially reversible (unlike mutations). For this reason, much attention has been placed over the past two decades on deriving pharmacological compounds that can specifically target and reverse such epi-mutations, either halting cancer on its developmental trajectory or reverting fully formed cancers to a more clinically manageable state. This review discusses DNA methyltransferase and histone deacetylase inhibitors that have been extensively studied in preclinical models and clinical trials for advanced and metastatic urological cancers.  
  Address Prostate Molecular Oncology, Institute of Molecular Medicine, Trinity College Dublin and St. James's Hospital  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-7258 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23353098 Approved no  
  Call Number @ @ Serial 37408  
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