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Author (up) Shukla, S.D.; Pruett, S.B.; Szabo, G.; Arteel, G.E.
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  Title Binge Ethanol and Liver: New Molecular Developments Type Journal Article
  Year 2013 Publication Alcoholism, Clinical and Experimental Research Abbreviated Journal Alcohol Clin Exp Res  
  Volume Issue Pages  
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  Abstract Binge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that binge EtOH has profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acute EtOH. Binge EtOH alters the levels of several cellular components and dramatically amplifies liver injury in chronically EtOH exposed liver. These studies highlight the importance of molecular investigations into binge effects of EtOH for a better understanding of ALD and also to develop therapeutic strategies to control it. This review summarizes these recent developments.  
  Address Department of Medical Pharmacology and Physiology , University of Missouri School of Medicine, Columbia, Missouri  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0145-6008 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23347137 Approved no  
  Call Number @ @ Serial 37434  
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