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Author (up) Perez-Campo, F.M.; Costa, G.; Lie-A-Ling, M.; Kouskoff, V.; Lacaud, G.
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  Title The MYSTerious MOZ, a Histone Acetyltransferase with a Key Role in Haematopoiesis Type Journal Article
  Year 2013 Publication Immunology Abbreviated Journal Immunology  
  Volume Issue Pages  
  Keywords  
  Abstract Cells of the immune system are generated from multipotent haematopoietic stem cells (HSCs) through an elaborated process of differentiation. Self-renewal of the HSC and a tightly controlled differentiation are therefore vital to replenish the blood and immune system throughout the lifespan of an organism. HSCs proliferation, as well as the successive stages of differentiation into more committed progenitors, are regulated at the transcriptional level through epigenetic modifications. These modifications include DNA methylation, histone modifications (such as acetylation, methylation, phosphorylation, SUMOylation and ubiquitylation) and chromatin remodeling. The enzymes responsible for these chromatin modifications are therefore critical for normal blood and immune system homeostasis. The finding that these chromatin modifiers are common targets of mutations or translocations in leukaemia further highlights their functional requirements. (c) 2013 The Paterson Institute for Cancer Research Immunology (c) 2013 Blackwell Publishing Ltd.  
  Address Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow road, M20 4BX, UK  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0019-2805 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23347099 Approved no  
  Call Number @ @ Serial 37436  
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