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Author (up) Centanni, T.M.; Booker, A.B.; Sloan, A.M.; Chen, F.; Maher, B.J.; Carraway, R.S.; Khodaparast, N.; Rennaker, R.; Loturco, J.J.; Kilgard, M.P.
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  Title Knockdown of the Dyslexia-Associated Gene Kiaa0319 Impairs Temporal Responses to Speech Stimuli in Rat Primary Auditory Cortex Type Journal Article
  Year 2013 Publication Cerebral Cortex (New York, N.Y. : 1991) Abbreviated Journal Cereb Cortex  
  Volume Issue Pages  
  Keywords  
  Abstract One in 15 school age children have dyslexia, which is characterized by phoneme-processing problems and difficulty learning to read. Dyslexia is associated with mutations in the gene KIAA0319. It is not known whether reduced expression of KIAA0319 can degrade the brain's ability to process phonemes. In the current study, we used RNA interference (RNAi) to reduce expression of Kiaa0319 (the rat homolog of the human gene KIAA0319) and evaluate the effect in a rat model of phoneme discrimination. Speech discrimination thresholds in normal rats are nearly identical to human thresholds. We recorded multiunit neural responses to isolated speech sounds in primary auditory cortex (A1) of rats that received in utero RNAi of Kiaa0319. Reduced expression of Kiaa0319 increased the trial-by-trial variability of speech responses and reduced the neural discrimination ability of speech sounds. Intracellular recordings from affected neurons revealed that reduced expression of Kiaa0319 increased neural excitability and input resistance. These results provide the first evidence that decreased expression of the dyslexia-associated gene Kiaa0319 can alter cortical responses and impair phoneme processing in auditory cortex.  
  Address School of Behavioral and Brain Sciences, University of Texas at Dallas  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1047-3211 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23395846 Approved no  
  Call Number @ @ Serial 37810  
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