Submit and Search Epigenetics Publications

1–1 of 1 record found matching your query (RSS):

Select All    Deselect All
 |   | 
Details
   print
  Record Links
Author (up) Hilakivi-Clarke, L.; de Assis, S.; Warri, A.
url  doi
openurl 
  Title Exposures to Synthetic Estrogens at Different Times During the Life, and Their Effect on Breast Cancer Risk Type Journal Article
  Year 2013 Publication Journal of Mammary Gland Biology and Neoplasia Abbreviated Journal J Mammary Gland Biol Neoplasia  
  Volume Issue Pages  
  Keywords  
  Abstract Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer risk. In this review, we discuss the findings that maternal exposure to the synthetic estrogen diethylstilbestrol during pregnancy increases breast cancer risk in both exposed mothers and their daughters. In addition, we review data regarding the use of estrogens in oral contraceptives and as postmenopausal hormone therapy and discuss the opposing effects on breast cancer risk based upon timing of exposure. We place particular emphasis on studies investigating how maternal estrogenic exposures during pregnancy increase breast cancer risk among daughters. New data suggest that these exposures induce epigenetic modifications in the mammary gland and germ cells, thereby causing an inheritable increase in breast cancer risk for multiple generations.  
  Address Department of Oncology, Georgetown University, Washington, DC, USA, clarkel@georgetown.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1083-3021 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23392570 Approved no  
  Call Number @ @ Serial 37812  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: