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Author (up) Lake, R.J.; Fan, H.-Y.
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  Title Structure, function and regulation of CSB: A multi-talented gymnast Type Journal Article
  Year 2013 Publication Mechanisms of Ageing and Development Abbreviated Journal Mech Ageing Dev  
  Volume Issue Pages  
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  Abstract The Cockayne syndrome complementation group B protein, CSB, plays pivotal roles in transcription regulation and DNA repair. CSB belongs to the SNF2/SWI2 ATP-dependent chromatin remodeling protein family, and studies from many laboratories have revealed that CSB has multiple activities and modes of regulation. To understand the underlying mechanisms of Cockayne syndrome, it is necessary to understand how the biochemical activities of CSB are used to carry out its biological functions. In this review, we summarize our current knowledge of the structure, function and regulation of CSB, and discuss how these properties can impact the biological functions of this chromatin remodeler.  
  Address Epigenetics Program, Department of Biochemistry and Biophysics, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0047-6374 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23422418 Approved no  
  Call Number @ @ Serial 37956  
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