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Author (up) do Nascimento Borges, B.; Burbano, R.M.R.; Harada, M.L.
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  Title Analysis of the methylation patterns of the p16 , p15 , and APC genes in gastric adenocarcinoma patients from a Brazilian population Type Journal Article
  Year 2013 Publication Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine Abbreviated Journal Tumour Biol  
  Volume Issue Pages  
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  Abstract Gastric cancer is a major public health problem in Para state, where studies suggest complex genetic and epigenetic profiles of the population, indicating the need for the identification of molecular markers for this tumor type. In the present study, the methylation patterns of three genes [p16 INK4A , p15 INK4B , and adenomatous polyposis coli (APC)] were assessed in patients with gastric adenocarcinoma from Para state in order to identify possible molecular markers of gastric carcinogenesis. DNA samples from tumoral and non-tumoral gastric tissues were modified with sodium bisulfite. A fragment of the promoter region of each gene was amplified and sequenced, and samples with more than 20 % of methylated CpG sites were considered hypermethylated. The correlation between the methylation pattern of the selected genes and the MTHFR C677T polymorphism, as well as the relationship between APC and CDH1 methylation, were evaluated. The results suggest that APC hypermethylation is an age-specific marker of gastric carcinogenesis, and the concordance of this event with CDH1 hypermethylation suggests that the Wnt pathway has an important role in gastric carcinogenesis. While the hypermethylation pattern of p15 INK4B seems to be an earlier event in this type of tumor, the hypomethylated status of this gene seems to be correlated to the C677T MTHFR TT genotype. On the other hand, the observed pattern of p16 INK4A hypermethylation suggests that this event is a good marker for the gastric cancer pathway in the Para state population.  
  Address Instituto Socioambiental e dos Recursos Hidricos (ISARH), Universidade Federal Rural da Amazonia, Avenida Presidente Tancredo Neves, 2501, Montese, 66077901, Belem, Para, Brazil, pithecia@gmail.com  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1010-4283 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23504555 Approved no  
  Call Number @ @ Serial 38519  
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