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Author (up) Kawai, N.; Kawanishi, M.; Kudomi, N.; Maeda, Y.; Yamamoto, Y.; Nishiyama, Y.; Tamiya, T.
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  Title Detection of brain amyloid beta deposition in patients with neuropsychological impairment after traumatic brain injury: PET evaluation using Pittsburgh Compound-B Type Journal Article
  Year 2013 Publication Brain Injury : [BI] Abbreviated Journal Brain Inj  
  Volume Issue Pages  
  Abstract Abstract Objective: Traumatic brain injury (TBI) is an epigenetic risk factor for Alzheimer's disease (AD) and amyloid beta (Abeta) deposition is observed histopathologically in the traumatized brain. This study was conducted to detect cerebral Abeta deposition using amyloid positron emission tomography (PET) in patients with neuropsychological impairment after TBI. Methods: Twelve patients with post-traumatic neuropsychological impairment (11 men and one woman, age range = 21-78 years) were examined using Pittsburgh Compound B (11C-PIB) PET at the chronic stage after TBI (range = 5-129 months). Results: 11C-PIB was positive in three patients and negative in the other nine patients. There was no correlation between 11C-PIB deposition and the severity of injury; initial CT findings; elapsed time from the injury; and neuropsychological test scores. Conclusions: The absence of Abeta deposition in many patients with chronic neuropsychological impairment after TBI does not support the premise that Abeta pathology progresses over time in the traumatized brain. Early and sequential 11C-PIB PET examination may clarify the time course of Abeta deposition in the traumatized brain and the relationship between traumatic brain insult and subsequent neuropsychological impairment.  
  Address Department of Neurological Surgery and  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0269-9052 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23662609 Approved no  
  Call Number @ @ Serial 39656  
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