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Author (up) Tsujiuchi, T.; Araki, M.; Hirane, M.; Dong, Y.; Fukushima, N.
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  Title Lysophosphatidic acid receptors in cancer pathobiology Type Journal Article
  Year 2013 Publication Histology and Histopathology Abbreviated Journal Histol Histopathol  
  Volume Issue Pages  
  Keywords  
  Abstract Lysophosphatidic acid (LPA) receptors (LPA1 to LPA6) are G protein-coupled transmembrane and mediate a variety of biological responses through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. Previously, high secretion levels of LPA were found in blood and ascites from patients with aggressive ovarian cancer. So far, numerical studies have demonstrated that LPA signaling via LPA receptors contributes to the acquisition of malignant potency by several cancer cells. Moreover, genetic and epigenetic alterations of LPA receptor genes have been detected in cancer cells. Therefore, it is suggested that LPA signaling may be a target molecule for the establishment of chemoprevention agents in clinical cancer approaches. Here, we review the current knowledge for the biological roles of LPA signaling via LPA receptors in the pathogenesis of cancer cells.  
  Address Division of Cancer Biology and Bioinformatics, Department of Life Science, Faculty of Science and Engineering, Kinki University, Higashiosaka, Osaka, Japan. ttujiuch@life.kindai.ac.jp  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0213-3911 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24194373 Approved no  
  Call Number @ @ Serial 43453  
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