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Author (up) Mann, D.A.
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  Title Epigenetics in Liver Disease Type Journal Article
  Year 2014 Publication Hepatology (Baltimore, Md.) Abbreviated Journal Hepatology  
  Volume Issue Pages  
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  Abstract Epigenetics is a term that encompasses a variety of regulatory processes that are able to crosstalk in order to influence gene expression and cell phenotype in response to environmental cues. A deep understanding of epigenetics offers the potential for fresh insights into the basis for complex chronic diseases and improved diagnostic and prognostic tools. Moreover, as epigenetic modifications are highly plastic and responsive to the environment there is much excitement around the theme of epigenetic therapeutics, including not only new drugs but also more informed patient advice on lifestyle choices and their impact on pathology. This review will briefly explain the molecular nature of the individual regulatory process that constitute epigenetics, including DNA methylation, histone modifications, chromatin remodeling, transcriptional control and non-coding RNAs. The ways in which these epigenetic mechanisms influence liver physiology and disease will be considered in detail particularly in the context of cancer, fibrosis and non-alcoholic steatohepatitis. The current limitations associated with epigenetic profiling and therapeutics in liver disease will be discussed, as will the intriguing possibility that environmental-induced epigenetic changes may become stable and heritable. The aim of the review is to inform hepatologists of the emerging key epigenetic ideas of relevance to the liver diseases and that are highly likely to form a component of patient management and care in the next decade. (Hepatology 2014;).  
  Address Fibrosis Research Laboratories, Institute of Cellular Medicine, 4th Floor, William Leech Building, Newcastle University, Newcastle upon, Tyne, NE24HH  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0270-9139 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24633972 Approved no  
  Call Number @ @ Serial 46113  
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